Latest TMS Research

Daily left prefrontal rTMS as monotherapy produced statistically significant and clinically meaningful antidepressant therapeutic effects greater than sham.

We tested whether Transcranial Magnetic Stimulation (TMS) over the left dorsolateral prefrontal cortex (DLPFC) is effective and safe in the acute treatment of major depression. 

This report describes the results of an open-label extension study of active trans-cranial magnetic stimulation (TMS) in medication-resistant patients with major depressive disorder who did not benefit from an initial course of therapy in a previously reported 6-week, randomized controlled study of active versus sham TMS.

Repetitive transcranial magnetic stimulation (rTMS) is efficacious in treatment-resistant depression when applied with high-frequency stimulation (HF-rTMS: 5 Hz to 25 Hz) over the left dorsolateral prefrontal cortex (PFC) and with low-frequency stimulation (LF-rTMS≤1 Hz) over the right dorsolateral PFC.1 rTMS is known to be painless and well-tolerated, and does not require, as a rule, either premedication or special biological monitoring.

Non-supression of the post-dexamethasone cortisol is a feature of endogenous/melancholia depression.  Normalization of the dexathemasone supression test response is a feature of remission and antidepressant treatment...

Repetitive transcranial magnetic stimulation (rTMS) is suggested to be a potentially useful treatment in major depression. In order to optimize rTMS for therapeutic use, it is necessary to understand the neurobiological mechanisms involved, particularly the nature of the neurochemical changes induced...

Dopamine is implicated in movement, learning, and motivation, and in illnesses such as Parkinson's disease, schizophrenia, and drug addiction. Little is known about the control of dopamine release in humans, but research in experimental animals suggests that the prefrontal cortex plays an important role in regulating the release of dopamine in subcortical structures...

Converging evidence points to hypofunction of the left prefrontal cortex in depression. Repetitive transcranial magnetic stimulation (rTMS) activates neurons near the surface of the brain. We questioned whether daily left prefrontal rTMS might improve mood in depressed subjects and report a pilot study of such treatment in six highly medication-resistant depressed inpatients...